The FDA’s emphasis on considering overall survival data, rather than just progression-free survival, is evident in its recent actions. The delay poses challenges for Abecma, as the therapy’s use has slowed with the approval of alternative multiple myeloma treatments, such as Carvykti. Moreover, Abecma’s Phase III study indicated a slightly higher death rate in the Abecma arm compared to standard care.
The delay is detrimental to 2seventy bio, which previously laid off 40% of its staff due to lower-than-expected Abecma sales. This setback caused a significant drop in the biotech company’s shares, which were already down 81% for the year.
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