PackGene provides preclinical grade plasmids that come with extensive and rigorous quality specifications and analysis, catering to all of your preclinical project requirements. They are perfectly suited for in vivo animal studies from mice to non-human primates, and are ideal for research use in gene therapy, cell therapy, and vaccine development. Quantities are available starting from 10 mg and beyond.
Comprehensive quality control of supercoil content and endotoxin levels
Animal- free production is available
Quantitative impurity analysis
Guaranteed quantity of mg to gram with material archiving option
| PackGene plasmid process | Preclinical |
| Clone screening | √ |
| Growth condition optimization | √ |
| High density fermentation | √ |
| Alkaline lysis | √ |
| Chromatographic purification | √ |
| Antibiotics free | √ |
| Consistent manufacturing process | √ |
| Instrument calibration/validation | Calibration |
| COA & CoC | COA |
| TSE/BSE | O |
| Test | Methods |
| Appearance | Visual inspection |
| A260:280 | Ultraviolet-visible spectrophotometry (A260/A280) |
| Homogeneity | HPLC |
| Restriction Analysis | Agarose gel |
| Residual RNA | SYBRGold |
| Residual E. coli DNA | qPCR |
| Endotoxin | LAL |
| Bioburden Testing | Direct inoculation |
| Sequencing | Sanger |
| Antibiotics Free Production | – |
| Residual Host Protein | HCP ELISA |
| Animal Free Production* | – |
| Mycoplasma Contamination | qPCR |
| Material Archiving | – |
| pH | Potentiometry |
| Kanamycin | ELISA |
| Sterility | |
| Osmolality |
Related Services
Plasmids GMP Services
Multiple scales & grade of solutions of various kind of plasmids suitable for multiple treatments in a fast and cost effective way
READ MORE
AAV GMP Services
Ranging from small-scale AAV production, to large-scale AAV cGMP manufacturing for animal studies
READ MORE
Technology Platforms
PackGene’s proprietary π-Alpha™ 293 AAV High-yield Platform increases AAV production by 3 to 8 times that of traditional platforms.
READ MORE