π-Omega Plasmid DNA High-yield Production Platform

Plasmid.Preparation
  • PackGene’s proprietary π-Omega Plasmid DNA High-yield Platform increases plasmid yield by more than 3 times through plasmid backbone modifications. Production scale can reach up to 200L, and single-batch production yields can reach up to 100 grams. As a key raw material in AAV production, plasmid DNA cost reduction greatly reduces AAV production cost while simultaneously meeting the growingly plasmids demand in the mRNA based therapeutics.

Pi-omega

Key Advantages

  • Cost Efficient

    Greatly reduces cost by two-step chromatography
  • Increase Yield

    High-yield plasmid production driven by proprietary plasmid backbone modifications
  • Quality

    Strain suitable for mRNA plasmid fermentation (maintaining the stability of polyA)

Intellectual Property

  • One patent is pending.

    Increases Yield about 3-4 times by Molecular Modification on Plasmid

    Increases Yield about 3-4 times by Molecular Modification on Plasmid

     

    Two-step Purification Process to Improve Plasmid Quality

    Two-step Purification Process to Improve Plasmid Quality

     

    Items 3-step 2-step
    HCD <5ug/mg <2ug/mg
    Supercoil >95% >95%
    Endotoxin <10EU/mg <10EU/mg
    HCP N/A N/A
    Recovery >40% >50%
    Remark stability High requirements for upstream stability

    Lower HCD & Higher Recovery Rate

     

    Yield of plasmid maintains in the same range

    Yield of plasmid maintains in the same range

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