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Digest: Gene Editing Therapeutics Based on mRNA Delivery

Overview This review article discusses the therapeutic potential of gene editing, focusing on mRNA-based delivery systems. It highlights the advancements in gene editing technologies like CRISPR-Cas systems and base editors, and examines their applications in treating...

Lou Gehrig’s Disease: Amyotrophic Lateral Sclerosis (ALS)

Amyotrophic lateral sclerosis (ALS), commonly known as "Lou Gehrig's disease," is a rare neurodegenerative condition and one of the world's five major incurable diseases. It is characterized by the gradual loss of neurons in the brain, brainstem, and spinal cord that...

Strategies for AAV Applications in the Nervous System

Adeno-associated virus (AAV) has many advantages such as small size, high safety, and low immunogenicity, making it widely used in the study of nervous system diseases. What key points should be considered for AAV applications in neural tissues?   Selection of...

AAV Serotype Screening System

Recombinant adeno-associated viruses (rAAV) are the most commonly used delivery vectors in gene therapy. However, naturally occurring AAVs with organ-targeting properties are very limited. In order to achieve more precise treatment goals, scientists have continuously...

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