Learning Center

AAV Immunogenicity: Challenges, Developments, and Innovations

Adeno-associated viruses (AAVs) have emerged as one of the most promising vectors for gene therapy due to their ability to efficiently deliver therapeutic genes to a wide range of tissues, their relatively low immunogenicity compared to other viral vectors, and their...

Riding Momentum in the DMD Space: A New Wave of Progress

Recently, topline results from Part 2 of Sarepta Therapeutics’ EMBARK trial showed significant improvements in motor function among Duchenne muscular dystrophy (DMD) patients who switched from placebo to Elevidys. These findings reinforce the potential of Elevidys to...

The Hidden Threat to AAV Purity: Uncovering Ferritin Contamination

Adeno-associated virus (AAV), valued for its low immunogenicity, broad tropism, and long-lasting in vivo gene expression, has emerged as the leading vector for gene therapy delivery. For AAV vectors intended for clinical use, the FDA requires stringent quality control...

AAV Vectors in Cancer Therapy: A Review of Applications and Strategies

1. Introduction Cancer continues to be a major health concern despite progress in traditional treatments like surgery, chemotherapy, and radiotherapy. Gene therapy provides an innovative approach by introducing therapeutic genes to cancer cells, enabling targeted...

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