Unlock the potential of plasmid DNA across multiple therapeutic approaches, from gene and cell therapies, viral vector production, and immunotherapeutics to mRNA/DNA vaccines and nucleic acid drugs. PackGene provides plasmid preparation services that are ideal for any phase of the drug development cycle including basic discovery research through commercialization at any scale.
Tailored QC Tests
Our range of quality control tests for endotoxin levels, supercoil content, residual contaminants, and sequence fidelity can be customized for your workflow.
|Research Grade||Preclinical Grade|
|Application||Molecular cloning, protein expression, transfection, viral packaging for research||Large scale viral packaging, animal studies|
|Timeline||as fast as 3 days||as fast as 2-3 weeks|
|Appearance||Clear, colorless, no visible particulates|
|A260:280||1.8 – 2.0|
|Homogeneity||Predominantly supercoiled||>90% HPLC|
|Restriction Analysis||Conforming to reference pattern|
|Residual RNA||N/A||Undetected by SYBRGold|
|Residual E. coli DNA||N/A||Quantitative PCR ≤1%|
|Endotoxin||≤100 EU/mg, optional LAL test*||≤10 EU/mg|
|Bioburden Testing||Optional*||No growth on agarose plate after 48 hours|
|Antibiotics Free Production||No||Optional|
|Residual Host Protein||–||<0.1% by HCP ELISA*|
|Animal Free Production*||–||TSE/BSE*|
|Mycoplasma Contamination||–||Quantitative PCR, Negative *|
|Material Archiving||Yes (plasmid only)||Yes (plasmid + bacteria) upon request *|
|pH||–||Potentiometry 7.5~8.0, USP <791> *|
|Kan||–||ELISA, <0.5ng/g *|
|Osmolality||–||USP <785> *|
|Advanced Endotoxin Removal <0.005 EU/µg||–||Available with additional charge|
|Dedicated purification resin||–||Upon request*|
|Buffer||ddH2O, TE or customer defined|
|Dedicated filtration membrane||–||Sterile filtration*|
*Tests marked need additional charges and time.
Synthesize new plasmids or re-prep previously synthesized ones.
Research Grade Plasmid
Fast, affordable, low-endotoxin plasmid DNA for viral vector engineering, high-throughput screening, or mRNA production among other applications.
Preclinical Grade Plasmid
Rigorous quality standards and analysis for your preclinical endeavors. Tailored for preclinical in vivo animal studies and suitable for a range of species from mice to non-human primates. Available in quantities starting from 10 mg.
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AAV Packaging Services
Ranging from pilot to industrial-scale AAV packaging for both in vitro and in vivo studies.
AAV Analytical Services
We are one of the few vendors that can do ALL in-house.
Off the Shelf AAV Products
We offer a wide catalogue of pre-made AAVs for a multitude of research needs.