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Decibel, Principal Scientist
“A lot of our programs internally have been having great results with the AAV vectors you all have been packaging. PackGene is rapidly becoming our go-to for AAV vectors! ”
Biogen Scientist
“I have spreaded the word of my satisfaction with your AAV vectors to many people in Biogen’s research labs and I hope we continue to be a regular customer in the future.”
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PCDH15 Dual-AAV Gene Therapy for Deafness and Blindness in Usher Syndrome Type 1F
BioRxiv. 2023 Nov 13 Maryna V. Ivanchenko, Daniel M. Hathaway, Eric M. Mulhall, Kevin T. Booth, Mantian Wang, Cole W. Peters, Alex J. Klein, Xinlan Chen, Yaqiao Li, Bence György and David P. Corey Products used in the paper Details Operation AAV vector AAVs were...
Optimization of base editors for the functional correction of SMN2 as a treatment for spinal muscular atrophy
Nature Biomedical Engineering. 2023 Dec 6 Christiano R. R. Alves, Leillani L. Ha, Rebecca Yaworski, Emma R. Sutton, Cicera R. Lazzarotto, Kathleen A. Christie, Aoife Reilly, Ariane Beauvais, Roman M. Doll, Demitri de la Cruz, Casey A. Maguire, Kathryn J. Swoboda,...
Intranasal mask for protecting the respiratory tract against viral aerosols
Nature Communications. 2023 Dec 18 Xiaoming Hu, Shuang Wang, Shaotong Fu, Meng Qin, Chengliang Lyu, Zhaowen Ding, Yan Wang, Yishu Wang, Dongshu Wang, Li Zhu, Tao Jiang, Jing Sun, Hui Ding, Jie Wu, Lingqian Chang, Yimin Cui, Xiaocong Pang, Youchun Wang, Weijin Huang,...
NeuroD1 and Ascl1 Convert Human Glial Cells into Neurons in Ex Vivo Culture of Human Brain Tissue
Research Square. 2023 Dec 14 Liang Xu, Qingsong Wang, Jiancheng Liao, Jiajun Zheng, Bing Qin, Wen Li, Jiaxuan Zhang, Wei Li, Xiangyu Wang, Maoying Zhang, Gong Chen Products used in the paper Details Operation AAV vector packaging Adeno-associated virus (AAV): AAV9...
Genome-wide study reveals novel roles for formin-2 in axon regeneration as a microtubule dynamics regulator and therapeutic target for nerve repair
Neuron. 2023 Dec 20 Ngan Pan Bennett Au, Tan Wu, Xinyu Chen, Feng Gao, Yuen Tung Yolanda Li, Wing Yip Tam, Kwan Ngok Yu, Daniel H. Geschwind, Giovanni Coppola, Xin Wang, and Chi Him Eddie Ma Products used in the paper Details Operation AAV vector packaging...
The Study on PLA-based nano-bio effects and its biomedical applications
. 2023 Aug DING Zhaowen Products used in the paper Details Operation was used as a negative control Request Quote Research Field: Coronavirus Keywords: PLA, nano-bio interfacial interaction, lamella nanomaterial, microsphere AAV Serotype: pseudovirus Animal or cell...
Regulation of myo-miR-24-3p on the Myogenesis and Fiber Type Transformation of Skeletal Muscle
Genes. 2024 Feb 21 Danyang Fan, Yilong Yao, Yanwen Liu, Chao Yan, Fanqinyu Li, Shilong Wang, Mei Yu, Bingkun Xie and Zhonglin Tang Products used in the paper Details Operation AAV vector packaging AAV1-hOTOF was developed by researchers at the Eye & ENT Hospital of...
Enhancing transduction efficiency of adeno-associated virus 9 by cell line engineering: implication for gene therapy potency assay
Biotechnology and Bioprocess Engineering. 2024 Feb 19 Nanyeong Go, Changhyun Ahn & Jae Young Lee Products used in the paper Details Operation AAV vector packaging In brief, mice were intranasally infected with AAV-hACE2 (PackGene Biotech, Guangzhou, China) Request...
Advanced Therapies Congress (Philly, PA, Nov 12-13)
Make your mark at the Advanced Therapies Congress in Philadelphia this November, where global leaders in gene and cell therapy, regenerative medicine, and related fields gather for top-tier education, scientific exchange, and networking. Exhibit your product or...
SITC (Houston, TX, Nov 6-10)
Join us at SITC's 39th Annual Meeting, the premier cancer immunotherapy conference, where global leaders from academia, industry, and government come together for cutting-edge education, scientific exchange, and networking. Showcase your product or service to advance...
ESGCT 2024 (Rome, Italy, Oct 22-25)
The ESGCT supports scientists and clinicians in gene and cell therapy, promoting research, collaboration, and awareness. With new delivery vectors and genome engineering advancements, more life-changing treatments are possible. Join us at the Annual Congress in Rome...
Advancing Gene and Cell Therapies for Cancer (Philly, PA, Oct 16-17)
Join ASGCT at the Wyndham Philadelphia Historic District, Oct. 16-17, 2024, for an unparalleled opportunity to immerse yourself in the latest research related to gene and cell therapy for cancer in Philadelphia's vibrant Historic District.Time: Oct 16-17, 2024Address:...
Webinar: Current Challenges and New Approaches to Developing rAAV Manufacturing Processes for Large-scale GMP Production
Abstract:Adeno-associated virus (AAV) production faces significant challenges, including low yields, scalability issues, and inconsistent quality. Scaling up AAV production to meet clinical and commercial demands requires innovative solutions. PackGene's proprietary...
Cell & Gene Meeting on the MESA (ARM; Phoenix, AZ, Oct 7-9)
The 2024 Cell & Gene Meeting on the Mesa is the premier annual conference for industry leaders, focused on innovative research and overcoming commercial challenges in cell and gene therapy. The event features expert panels, networking opportunities, and over 100...
Socienty for Neuroscience (Chicago, IL, Oct 5-9)
Annually, scientists from across the globe gather to explore new concepts, present their research, and experience the pinnacle of their field. By attending, you can present your own research, network with fellow scientists, participate in sessions and events, and...
CASSS-CGTP ( Rockville, MD, Jun 11-13)
The Cell and Gene Therapy Products (CGTP) Symposium focuses on Manufacturing, Quality, and Regulatory Considerations, fostering an exchange of scientific ideas and interactions with regulators that shape evolving regulatory frameworks for these innovative products....
[2024/12/06] Gene and Cell Therapy- weekly digest from PackGene
FeaturedNewsArticlesPackGene's NewsletterReceive the latest news and insights to your inbox.About PackGenePackGene Biotech is a world-leading CRO and CDMO, excelling in AAV vectors, mRNA, plasmid DNA, and lentiviral vector solutions. Our comprehensive offerings span...
Prime Editing: Precision Gene Therapy on the Horizon
The world of gene editing is evolving rapidly, and prime editing is emerging as a standout innovation. Known for its precision and versatility, this technique has taken center stage in therapeutic research, promising transformative advancements for genetic diseases. A...
Rgenta Therapeutics and GSK Forge Strategic Alliance to Advance RNA-Targeted Small Molecule Medicines
Woburn, Mass. – December 4, 2024 – Rgenta Therapeutics, a clinical-stage biotechnology company specializing in RNA-targeted small molecule therapies, has announced a multi-year strategic research alliance with pharmaceutical giant GSK. The partnership will focus on...
RNA-targeting molecule from Arrakis allows muscles to relax in mice with myotonic dystrophy
"Dune"-inspired Arrakis Therapeutics has tested its spice—an RNA-targeting small molecule—in a mouse model of myotonic dystrophy type 1 (DM1), with the drug reversing the prolonged muscle contraction that is characteristic of the disease. Arrakis, based not on a...
Researchers discover cell-type-specific link between alternative splicing and autoimmune disease inheritance
Population-scale 5′ scRNA-seq identified 21 cell types and thousands of alternatively spliced genes per cell type. Credit: Nature Genetics (2024). DOI: 10.1038/s41588-024-02019-8Computational biologists from the National University of Singapore (NUS) have uncovered...
Bluebird and Vertex’s sickle cell gene therapies to kick off new Medicaid access model
The Biden Administration said Wednesday that it has secured agreements with Vertex Pharmaceuticals and bluebird bio for their sickle cell disease gene therapies to be the first in a new access model from the Centers for Medicare and Medicaid Services. The voluntary...
Private Medicare insurers are likely to benefit in Trump’s new administration
Medicare Advantage insurers thrived under the first Trump administration, and it’s expected to happen again now that Trump is returning to the White House and Republicans are taking control of Congress. The Medicare Advantage program is expected to cost taxpayers and...
Cartesian tees up Phase 3 mRNA CAR-T study in myasthenia gravis
Cartesian Therapeutics reported longer-term results from a mid-stage study of its mRNA CAR-T therapy for myasthenia gravis, suggesting that the therapy is durable beyond the initial three-month study period. In 12 patients, the mean decrease at six months in a...
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