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AAV-miRNA inhibition

PackGene offers custom inhibitory miRNA AAV vectors that can be used to inhibit endogenous miRNA expression and function in live animals.

Interested in our AAV services? Please contact us for a free consultation or  submit a request for a quotation.

miRNA are small non-coding RNAs that are endogenously expressed in eukaryotes and play important role in regulating gene expression. miRNA inhibitors are RNA molecules that are designed as reverse compliment sequence to endogenous miRNA and functionally block their gene regulation capabilities.

Key properties:

  • Direct, convenient, and efficient expression of miRNA inhibitors for in vivo animal experiments
  • Geater expression durability and longer effect duration when compared to traditional synthetic miRNA inhibitors
  • Ability to target various organs and tissues through specific AAV serotypes
  • Increased safety and immunogenicity relative to traditional synthetic miRNA inhibitors