AAV-miRNA & Other Cloning
PackGene offers custom miRNA inhibitory AAV vectors that can be used directly to inhibit miRNA function and regulate miRNA expression in live animals. This is a common method for in vivo animal genetic studies.
miRNA is an endogenous small non-coding RNA in eukaryotes with a length of about 17-25 bp. miRNA loss-of-function studies focus on screening for miRNA target sites, screening for miRNAs that regulate gene expression, and screening for miRNAs that affect growth and proliferation.
- Direct, convenient and efficient animal experiments
- Longer duration of action and greater stability than traditional synthetic inhibitors
- Ability to target various organs and tissues through specific AAV serotypes
- AAV-miRNAs show increased safety and immunogenicity