Traditional knock-in animal models are labor-intensive and require at least six months to build. PackGene has generated animal models that overexpress the hACE2 protein in specific organs, making them suitable for COVID-19-related studies.

PackGene applies the rAAV virus vector to infect specific mice organs to obtain the AAV-hACE2 animal model. The tissues in mice can continuously and stably express hACE2 protein, which is a simple and time-saving operation for new coronavirus-related drug development and research.

Comparison between AAV-hACE2 animal modeling and traditional animal modeling

AAV-hACE2 animal modeling
Traditional animal modeling

Production Cycle

Short cycle within 14 days
Over 6 months


Complicated steps


Specific distribution
Wide distribution