Online Order Get In Touch

What are you looking for?

π-Alpha 293 AAV High-yield Production Platform

  • PackGene's proprietary π-Alpha 293 AAV High-Yield Platform represents a significant advancement in Adeno-Associated Virus (AAV) production and quality. The platform integrates an optimized PCS3.0 suspension cell line and a uniquely engineered RC plasmid within a triple-plasmid transfection system, achieving a 3 to 8-fold increase in AAV production across diverse serotypes. This foundational enhancement, coupled with rigorous Quality by Design (QbD) optimizations throughout both upstream and downstream processes, culminates in up to a 10-fold overall yield improvement. The platform consistently delivers single-batch yields reaching 1E+17 vg, effectively meeting the demands of clinical and commercial-scale AAV production.

Pi-alpha
Contact Us

Key Advantages

  • Enhanced Productivity and Scalability

    Proprietary technologies drive a greater than 10-fold increase in AAV yield within HEK293 serum-free cell suspension systems. 

  • Superior Purity

    Refined process development significantly reduces key impurities, including Host Cell DNA (HCD) and endotoxin. 

  • Improved Safety and Bioactivity

    Innovative technological advancements minimize empty capsid and maximize infection titers.

Performance

  • Enhanced Productivity and Scalability

    The PCS3.0 suspension cell line, combined with a uniquely engineered RC plasmid, enhances AAV production efficiency. This optimized system enables greater scalability for large-scale manufacturing.

    PackGene’s proprietary RC plasmid significantly increases AAV production yield

    Fig 1. PackGene’s proprietary RC plasmid significantly increases AAV production yield

     

    Enhanced-Productivity-and-Scalability

  • Superior Purity

  • Improved safety and bioactivity

Contact Us

Download

Login

Don't have an account? Please register
Account*
Password*
Code*
Refresh
Forgot password?
Logging in indicates that you have read and accepted the Registration Agreement and User Agreement
Log in with other accounts

New User Registration

Already have an account?
First Name*
Middle Name
Last Name*
Organization*
Organization Type*
Country/State*
Email Address*
Code*
Set Password*
Confirm password*
Refferal Code*

Reset Password

Return to
Email*
Code*
New password*
Confirm password*

Google Account Binding

Organization*
Organization Type*
Country/State*