Innovations in AAV Production: Leveraging High-Yield Cell Lines, novel RC plasmid, and Dual-Plasmid Systems
Abstract PackGene has pioneered innovative approaches to meet the escalating demand for high-quality adeno-associated virus (AAV) vectors across the dynamic landscape of gene therapy. For example, PackGene achieves remarkable enhancements in AAV packaging efficiency...
The principles and advantages of constructing self-complementary double-stranded AAV (scAAV)
Recombinant adeno-associated virus (rAAV) serves as a gene delivery vector in vivo, where the necessary condition for transcription to proceed is the conversion of the genome sequence from single-stranded AAV (ssAAV) to double-stranded AAV. When it comes to the...
AAV Serotype Screening System
Recombinant adeno-associated viruses (rAAV) are the most commonly used delivery vectors in gene therapy. However, naturally occurring AAVs with organ-targeting properties are very limited. In order to achieve more precise treatment goals, scientists have continuously...
Adeno-associated virus (AAV) Packaging: A Comprehensive Exploration of its Packaging, Mechanisms, and Diverse Applications
Adeno-associated virus (AAV) is a member of the Parvoviridae family, a type of non-enveloped icosahedral virus with a diameter of approximately 20-26 nm and containing around 4.7 kb of linear single-stranded DNA as its genome. Recombinant adeno-associated virus (rAAV)...
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