Plasmid DNA High-yield Production Platform

Overview

PackGene’s proprietary π-Omega Plasmid DNA High-yield Platform increases plasmid yield by more than 3 times through plasmid backbone modifications. Production scale can reach up to 200L, and single-batch production yields can reach up to 100 grams. As a key raw material in AAV production, plasmid DNA cost reduction greatly reduces AAV production cost while simultaneously meeting the growingly plasmids demand in the mRNA based therapeutics.

Advantages

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Cost Efficient

Greatly reduces cost by two-step chromatography

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Increase Yield

High-yield plasmid production driven by proprietary plasmid backbone modifications

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Quality

Strain suitable for mRNA plasmid fermentation (maintaining the stability of polyA)

Intellectual Property

One patent is pending.

Increases Yield about 3-4 times by Molecular Modification on Plasmid

Increases Yield about 3-4 times by Molecular Modification on Plasmid

Two-step Purification Process to Improve Plasmid Quality

Two-step Purification Process to Improve Plasmid Quality

Items 3-step 2-step
HCD <5ug/mg <2ug/mg
Supercoil >95% >95%
Endotoxin <10EU/mg <10EU/mg
HCP N/A N/A
Recovery >40% >50%
Remark stability High requirements for upstream stability

Lower HCD & Higher Recovery Rate

Yield of plasmid maintains in the same range

Yield of plasmid maintains in the same range

Contact Us

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