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π-Omega™ Plasmid DNA High-yield Production Platform

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PackGene’s proprietary π-Omega™ Plasmid DNA High-yield Platform increases the plasmid yield by more than 3 times through plasmid backbone modifications. Production scale can reach up to 200L, and single-batch production yields can reach up to 100 grams. As a key raw material in AAV production, plasmid DNA cost reduction greatly reduces AAV production cost, while simultaneously meeting the growingly plasmids demand in the mRNA therapeutic field.

Advantages of the π-Omega™ Plasmid DNA High-yield Platform:

  • Cost efficient: Greatly reduces cost by two-step chromatography
  • Increase Yield: High-yield plasmid production driven by proprietary plasmid backbone modification
  • Quality: Strain suitable for mRNA plasmid fermentation (maintaining the stability of polyA)
Interested in our AAV services? Please contact us for a free consultation or  submit a request for a quotation.

Intellectual property:

PackGene has one patents pending.

Increases Yield about 3-4 times by Molecular Modification on Plasmid

Two-step-Purification-Process-to-Improve-Plasmid-Quality

Two-step Purification Process to Improve Plasmid Quality

Items 3-step 2-step
HCD <5ug/mg <2ug/mg
Supercoil >95% >95%
Endotoxin <10EU/mg <10EU/mg
HCP N/A N/A
Recovery >40% >50%
Remark stability High requirements for upstream stability

Lower HCD & Higher Recovery Rate

Yield of plasmid maintains in the same range