In an exclusive interview with Endpoints News, CEO Nathaniel Wang said his company plans to raise a Series B round based on the rabies data. But without a pharma or government partner, Replicate is unlikely to advance the rabies shot into a larger study, he added.
Instead, the startup is shifting its focus to a previously undisclosed program, an mRNA shot for Epstein-Barr virus, which Replicate will test in a clinical trial next year, Wang said. There’s no approved vaccine to protect against EBV, which causes infectious mononucleosis in adolescents. Interest in efforts to stop the virus has increased since scientists linked EBV to the development of multiple sclerosis in 2022.
Replicate’s vaccines encode instructions for making viral proteins along with molecular photocopy machines that churn out more protein blueprints, mimicking a natural viral infection. The startup hopes its self-replicating RNA approach will lead to stronger and more durable immune responses with lower doses and fewer side effects.
The preliminary results, announced Wednesday via press release, indicate that one or two injections of the shot spurred potentially protective immune responses with doses as low as one-tenth of a microgram — between 300 and 1,000 times lower than what’s used in the Moderna and Pfizer-BioNTech primary vaccines and boosters for Covid-19. Replicate said there were no severe adverse events.
Other companies are developing similar vaccine technologies, including Arcturus Therapeutics, which won approval from Japanese regulators in November for a Covid vaccine, and Gritstone bio, which is also developing a next-gen Covid shot as part of the US government’s follow-up to Operation Warp Speed.
Replicate decided to test its vaccine technology in rabies first because it gives the company a clean read of how good the shots are at spurring an immune response.
“If you do a flu or Covid-19 trial, everyone has already been vaccinated,” Wang said. “With rabies, it’s easy to find people who haven’t been vaccinated, or bitten by a bat or raccoon.”
The study measured whether levels of neutralizing antibodies in the blood passed the World Health Organization’s threshold for protection against rabies.
“We’re seeing the substantive majority of subjects protected after two doses,” Wang said. Until now, no one has crossed the threshold of at least 50% protection with that low of a dose, he added.
But Replicate didn’t disclose the exact proportion of vaccine recipients who passed that threshold at each dose, or detail the frequencies and kinds of side effects that the study volunteers experienced. Wang said these details will be presented at a medical meeting this year.
Replicate also plans to begin a clinical trial of an off-the-shelf vaccine for breast cancer in 2025, Wang said. BioNTech, Gritstone bio and Moderna are also developing their own mRNA cancer vaccines customized to match the unique genetic makeup of a patient’s tumor.
https://endpts.com/replicate-bioscience-takes-aim-at-mono-causing-virus-after-promising-results-with-mrna-rabies-shot/
![GMP mRNA](https://static.packgene.com/wp-content/uploads/2023/05/GMP-mRNA.jpg)
Check out our mRNA service to expedite your vaccine research
PackGene Biotech is a world-leading CRO and CDMO, excelling in AAV vectors, mRNA, plasmid DNA, and lentiviral vector solutions. Our comprehensive offerings span from vector design and construction to AAV, lentivirus, and mRNA services. With a sharp focus on early-stage drug discovery, preclinical development, and cell and gene therapy trials, we deliver cost-effective, dependable, and scalable production solutions. Leveraging our groundbreaking π-alpha 293 AAV high-yield platform, we amplify AAV production by up to 10-fold, yielding up to 1e+17vg per batch to meet diverse commercial and clinical project needs. Moreover, our tailored mRNA and LNP products and services cater to every stage of drug and vaccine development, from research to GMP production, providing a seamless, end-to-end solution.
Related News
Exploring Tau Protein’s Role in Glaucoma: New Insights and Therapeutic Potential
Glaucoma, a chronic neurodegenerative disorder, leads to irreversible vision loss by damaging retinal ganglion cells (RGCs) and the optic nerve, often associated with increased intraocular pressure (IOP). Despite the benefits of IOP-lowering treatments, the underlying...
FDA-mandated CAR-T monitoring period could be halved, say researchers
In patients with diffuse large B-cell non-Hodgkin lymphoma (DLBCL), the two hallmark post-chimeric antigen receptor (CAR)-T therapy toxicities are extremely rare after two weeks, supporting a shorter, more flexible toxicity monitoring period, according to a study...
Ancestral CRISPR-Cas13 Ribonucleases Discovered: Implications for Genome Editing
In a pioneering study published in *Science*, a team of researchers led by Peter H. Yoon and Jennifer A. Doudna from the University of California, Berkeley, has made a remarkable discovery in the realm of CRISPR technology. The team has identified an ancestral clade...
KBI Biopharma Expands Manufacturing Contract with Global Pharmaceutical Company
KBI Biopharma Inc., a JSR Life Sciences company and global cGMP contract development and manufacturing organization (CDMO), has extended and expanded its manufacturing contract with a leading global pharmaceutical company. Originally initiated in 2020, the renewed...
Related Services
![](https://static.packgene.com/wp-content/uploads/2023/01/9-1.png)
Plasmids GMP Services
![](https://static.packgene.com/wp-content/uploads/2023/01/10-2.png)
AAV GMP Services
![aav icon](https://static.packgene.com/wp-content/uploads/2023/01/9-1.png)