Online Order Get In Touch

What are you looking for?

AAV Packaging - NHP Grade

Premium AAV Packaging specifically designed for Non-Human Primates studies

  • What we provide

    Non-human primate (NHP) studies often involve larger animals that require higher doses of adeno-associated virus (AAV) vectors. Low-quality AAV vectors can trigger immune responses or increase toxicity in animals. To mitigate these risks and improve the quality and reproducibility of NHP studies, PackGene offers high-quality NHP-grade AAV vectors with accurate measurement of virus quantity, genome integrity, empty capsid rate, and strict contamination control. By using PackGene's high-quality NHP-grade AAV vectors, researchers can lower the safety risks, enhance efficacy, and generate more reliable and reproducible results in their NHP studies.

lab
Contact Us

Key Benefits

  • Endotoxin and Contamination control

  • Precisely quantified Titer, Genome copy and integrity

  • Lower safety risks and enhance efficacy

  • Reproducible results

Service Details

AAV type Scale Turnaround time
Standard capsids (guaranteed yield) 1E+13 GC~8E+15 GC Start from 17 business days
Custom capsids (by volume) Up to 100L with 30mL-200mL small scale test Start from 25 business days

AAV yield depends on factors like serotype and gene of interest. We offer guaranteed packages for high-yield serotypes (1, 3b, 5, 7, 8, 9, Rh10). For other serotypes, we produce based on volume and can conduct small-scale tests to determine necessary production. Contact technical support for more details.

 

QC Standards

NHP grade AAV undergoes stringent QC tests before being released to ensure the quality of the AAV product and minimize the adverse effects in animal studies.

Test Method QC Standard
Standard QC ddPCR Measure titer, normalized to 1e13vg/ml Standard capsids: Concentration and total quantity meet needs. Custom capsids: quantity based on production scale.
AAV Capsid size* SDS-PAGE silver stain Match capsid protein size
Guarantee endotoxin LAL <1EU/ml
Mycoplasma Detection qPCR Negative
Bioburden Direct inoculation No growth
AAV Genome integrity CE(titer＞1e+12vg/ml, volume ＞50ul) Report
Empty Capsid Rate TEM <20%
Additional QC AAV Genome sequencing Nanopore Report
Empty Capsid Rate AUC Report
Endotoxin removal LAL <0.2EU/ml
Residual Triton Analysis (bundle with endo removal) HPLC 5ppm
Sterility test Direct inoculation No growth

 

Performance

  • Comprehensive Testing for AAV Quality, Purity, and Safety, Ensuring Suitability for NHP Studies

    NHP-studies

  • Ensuring Plasmid Integrity: Double-Check of ITR and GOI for High-Quality NHP-Grade AAV Production

REQUEST A QUOTE

Download