Merck KGaA to Acquire Silence Therapeutics for $1.3B, Moving into RNAi

Oct 19 , 2026
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Oct 19, 2026 —

Merck KGaA has agreed to acquire UK-based Silence Therapeutics for about $1.3 billion, buying its way into RNA interference (RNAi) medicine. The lead asset has posted positive Phase 2 data in the rare blood disorder polycythemia vera.

RNAi drugs use small interfering RNA (siRNA) to silence disease-causing genes, a modality that has matured quickly, mostly in liver-expressed targets. The deal terms imply a roughly 130% premium to Silence’s share price.

The acquisition is part of a busy stretch for RNA-medicine dealmaking, as larger drugmakers move to secure siRNA platforms and pipelines.

Source:

https://www.biopharmadive.com/news/merck-kgaa-rnai-13b-silence-buyout-blood-disorder-polycythemia-vera/833336/

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