-
Assessing Mass Photometry as a Robust Method for Characterizing Adeno-Associated Virus Critical Quality Attributes in Gene Therapy Vector
Author:
Guangyu Wang, Lei Yu, Xi Qin, Zexin Zhou, Yong Zhou, Chenggang Liang
Journal: Molecular Therapy
Doi: https://www.doi.org/10.1016/j.omtn.2025.102582
Sep 09 2025 -
Growth factor independence 1 ameliorates osteoarthritis by inhibiting chondrocyte ferroptosis via inactivation of MAPK signaling pathway
Author:
Xiaoyu Jin, Xunhao Wang, Siyu Xu, Nuo Xu, Ziwei Wang, Chunqing Hu, Wei Liu, Zhaofeng Zhang, Xiyu Liu, Jingjing Fan, Ruiyang Jiang, Rui Wu, Zhongyang Lv, Dongquan Shi
Journal: Journal of Orthopaedic Translation
Doi: https://www.doi.org/10.1016/j.jot.2025.07.003
Sep 01 2025 -
MicroRNA-106a-5p alleviates chronic constriction injury-induced neuropathic pain by targeting ten-eleven translocation 2 in a rat model
Author:
Lei Xu, Jihong Zhang, Long Wang
Journal: Neurological Research
Doi: https://www.doi.org/10.1080/01616412.2025.2538896
Jul 31 2025 -
Negatively charged α-Synuclein condensate modulates partitioning of molecules
Author:
Qingqing Yang, Shunfa Chen, Pengfei Zhang, Zhonghua Lu, Shuwen Chang, Leo E. Wong
Journal: Journal of Biological Chemistry
Doi: https://www.doi.org/10.1016/j.jbc.2025.110530
Jul 26 2025 -
Mouse B cells engineered to express an anti-HPV antibody elicit anti-tumor T cell responses
Author:
Michal Guberman Bracha, Guy Biber Guy Biber, Natalie Zelikson, Sharon Shavit, Roy Avraham, Yaron Vagima, Débora Rosa Bublik, Yael Katz, Adi Barzel, Leah Natasha Klapper, Shmuel Hess, Alessio David Nahmad
Journal: Frontiers in Immunology
Doi: https://www.doi.org/10.3389/fimmu.2025.1613879
Jul 18 2025 -
Engineering a human-based translational activator for targeted protein expression restoration
Author:
Riley W. Sinnott, Ani Solanki, Anitha P. Govind, William N. Green, Bryan C. Dickinson
Journal: BioRxiv
Doi: https://www.doi.org/10.1101/2025.07.09.663984
Jul 09 2025 -
FGF13 prevents age-related hearing loss by protecting spiral ganglion neurons and ribbon synapses from injury
Author:
Huan Yin, Huan Cao, Jianwang Yang, Tao Liu, Qi Li, Mengxiao Liu & Baoshan Wang
Journal: Cell Death Discovery
Doi: https://www.doi.org/10.1038/s41420-025-02607-5
Jul 05 2025 -
Tumor site-directed A1R expression enhances CAR T cell function and improves efficacy against solid tumors
Author:
Kevin Sek, Amanda X Y Chen, Thomas Cole, Jesse D Armitage, Junming Tong, Kah Min Yap, Isabelle Munoz, Phoebe A Dunbar, Shiyi Wu, Marit J van Elsas, Olivia Hidajat, Christina Scheffler, Lauren Giuffrida, Melissa A Henderson, Deborah Meyran, Fernando Souza-Fonseca-Guimaraes, Dat Nguyen, Yu-Kuan Huang, Maria N de Menezes, Emily B Derrick, Cheok Weng Chan, Kirsten L Todd, Jack D Chan, Jasmine Li, Junyun Lai, Emma V Petley, Sherly Mardiana, Anthony Bosco, Jason Waithman, Ian A Parish, Christina Mølck, Gregory D Stewart, Lev Kats, Imran G House, Phillip K Darcy, Paul A Beavis
Journal: Nature Communications
Doi: https://www.doi.org/10.1038/s41467-025-59021-9
Jul 03 2025 -
Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery
Author:
Amanda X. Y. Chen, Kah Min Yap, Joelle S. Kim, Kevin Sek, Yu-Kuan Huang, Phoebe A. Dunbar, Volker Wiebking, Jesse D. Armitage, Isabelle Munoz, Kirsten L. Todd, Emily B. Derrick, Dat Nguyen, Junming Tong, Cheok Weng Chan, Thang X. Hoang, Katherine M. Audsley, Marit J. van Elsas, Jim Middelburg, Joel N. Lee, Maria N. de Menezes, Thomas J. Cole, Jasmine Li, Christina Scheffler, Andrew M. Scott, Laura K. Mackay, Jason Waithman, Jane Oliaro, Simon J. Harrison, Ian A. Parish, Junyun Lai, Matthew H. Porteus, Imran G. House, Phillip K. Darcy & Paul A. Beavis
Journal: Nature
Doi: https://www.doi.org/10.1038/s41586-025-09212-7
Jul 02 2025 -
AAV gene therapy for autosomal recessive deafness 9: a single-arm trial
Author:
Jieyu Qi, Liyan Zhang, Ling Lu, Fangzhi Tan, Cheng Cheng, Yicheng Lu, Wenxiu Dong, Yinyi Zhou, Xiaolong Fu, Lulu Jiang, Chang Tan, Shanzhong Zhang, Sijie Sun, Huaien Song, Maoli Duan, Dingjun Zha, Yu Sun, Xia Gao, Lei Xu, Fan-Gang Zeng & Renjie Chai
Journal: Nature Medicine
Doi: https://www.doi.org/10.1038/s41591-025-03773-w
Jul 02 2025 -
Single‐Nucleus Transcriptomics Uncovers Xaf1‐Driven PANoptosis as a Therapeutic Target in Aminoglycoside‐Induced Hearing Loss
Author:
Xinlin Wang, Hairong Xiao, Jiheng Wu, Yanqin Lin, Yiheng Ao, Zixuan Ye, Xin Tan, Fanliang Kong, Xin Chen, Renjie Chai, Shasha Zhang
Journal: Cell Proliferation
Doi: https://www.doi.org/10.1111/cpr.70081
Jul 02 2025 -
Brainstem catecholaminergic neurons induce torpor during fasting by orchestrating cardiovascular and thermoregulation changes
Author:
Mingxiu Cheng, Meiqi Wang, Liang Wang, Fangfang Yin, Jiayi Shen, Xin Xing, Yuyan Shi, Zhiwei Liu, Ping Wu, Wenling Gao, Yanyan Fan, Peng Cao, Cheng Zhan
Journal: Nature Communications
Doi: https://www.doi.org/10.1038/s41467-025-61179-1
Jul 01 2025