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AAV Analytical Services

  • Comprehensive AAV testing covering titer, purity, safety, and more
  • Fast, reliable results with expert guidance
  • Tailored solutions ensuring top quality and safety standards
Mass Photometry

  • AAV Titration

    Measures the quantity and functionality of AAV vectors to ensure consistent production, proper dosing, and reproducibility. This includes genome copy number, capsid particle counts, and infectious titers, which are critical for quality control and downstream applications in research and therapeutic development.

    Tests:

    • AAV Genome Titration by ddPCR
    • AAV Capsid Titration by ELISA
    • Infectious Titer by TCID50
    • Capsid Titer by SEC-HPLC

  • Genome Integrity

    Measures the integrity and identity of AAV genomes to ensure accurate sequence, genome integrity, and full genome population for downstream applications. Techniques assess the complete genome from ITR to ITR, detect structural abnormalities, and confirm identity.

    Tests:

    • AAV Genome Integrity by Capillary Electrophoresis
    • AAV Genomic Sequencing by NanoporeSequencing
    • AAV Identity by Sanger Sequencing
    • AAV Genome Integrity by Alkaline Gel Electrophoresis

  • Capsid Characterization and Structural Analysis

    Evaluates AAV capsid integrity, empty capsid content, particle structure, and protein composition to ensure quality and consistency of viral preparations.

    Tests:

    • AAV Empty Capsid Rate by AUC
    • AAV Capsid Imaging by TEM (5 Pictures + Report)
    • AAV Hydrodynamic Size and Aggregation by DLS
    • AAV Capsid Peptide Mapping by HPLC-MS/MS
    • Capsid Protein Molecular Weight and Ratio by RP-HPLC-MS

  • Capsid Purity, Aggregation, and Physical Properties

    Assesses capsid purity, aggregation, subvisible particles, and appearance to guarantee consistency and suitability for downstream applications.

    Tests:

    • Capsid Purity by SDS-PAGE
    • Capsid Purity by CE-SDS
    • Purity Analysis by AEC-HPLC
    • Purity and Aggregation Analysis by SEC-HPLC
    • AAV Appearance by Visual Inspection
    • Subvisible Particles by Light Obscuration
    • Osmolarity by Freezing Point

  • Contaminants: Residual DNA and Protein

    Ensures AAV preparations are free from residual host cell DNA, plasmids, viral fragments, and proteins, supporting vector purity, safety, and reproducibility.

    Tests:

    • Residual Host HEK293 Cell DNA Quantification by qPCR
    • Residual HEK293 Host Cell DNA Sizing by qPCR
    • Residual Plasmid DNA by ddPCR
    • Residual E1A by ddPCR
    • Residual Host Cell Protein by ELISA
    • Residual BSA by ELISA
    • Residual Nuclease by ELISA
    • Residual Affinity Ligands by ELISA

  • Contaminants: Residual Reagents and Chemicals

    Measures residual purification reagents and excipients to ensure safety and suitability for downstream applications.

    Tests:

    • Residual PEI by HPLC
    • Residual Tween 20 by HPLC
    • Residual Triton X100 by HPLC
    • Residual Iodixanol by HPLC
    • Residual Poloxamer 188 by HPLC
    • Residual Triton Analysis (Bundle with Endo Removal) by HPLC
  • AAV Titration
  • Genome Integrity
  • Capsid Characterization and Structural Analysis
  • Capsid Purity, Aggregation, and Physical Properties
  • Contaminants: Residual DNA and Protein
  • Contaminants: Residual Reagents and Chemicals
AAV Analytical Service
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Key Benefits

  • Extensive Capabilities

  • Timely Results

  • Uncompromising Quality

  • Safety Assurance

  • Expert Guidance

  • Tailored Solutions

Service Details

We offer more than 40 standarized AAV quality assays.

Category SKU# Test Method Timeline(Business Days)
Titration AAVQC001-001 AAV Genome Titration
<ddPCR>		 ddPCR 5
AAVQC001-002 Custom ddPCR probe and primer synthesis – 5-7
AAVQC001-003 AAV Capsid Titration ELISA 5
AAVQC001-004 Infectious Titer
<TCID50>		 Serial Dilution and qPCR 21
Genome Integrity AAVQC002-001 AAV Genomic Integrity
<CE>		 CE 5
AAVQC002-002 AAV Genomic Sequencing
<TGS>		 3rd Generation Sequencing 5-10
AAVQC002-003 AAV Identity by Sanger sequencing Sanger sequencing 3-5
AAVQC002-004 Alkaline Gel Electrophoresis Agarose gels 6
Capsid characterization, purity and aggregation AAVQC003-001 AAV Empty Capsid Rate
<AUC>		 AUC to analyze empty capsid rate 5
AAVQC003-002 TEM (5 pictures) +report TEM 3-5
AAVQC003-003 DLS (Dynamic light scattering) Dynamic light scattering 5
AAVQC003-004 AAV Capsid Peptide Mapping HPLC-MS/MS 21
AAVQC003-005 Capsid Protein Molecular Weight and Ratio RP-HPLC-MS 21
AAVQC003-006 Capsid purity Analysis
<SDS-PAGE>		 SDS-PAGE with Silver Staining 2-3
AAVQC003-007 Capsid purity Analysis
<SDS-PAGE>		 SDS-PAGE with Coomassie Blue Staining 5
AAVQC003-008 Capsid purity Analysis
<CE-SDS>		 CE-SDS 5
AAVQC003-009 Purity Analysis
<AEC-HPLC>		 AEC-HPLC 5
AAVQC003-010 Purity and Aggregation Analysis
<SEC-HPLC>		 SEC-HPLC 5
HAAVQC003-011 Full Empty Ratio by Mass Photometry Mass Photometry 2
AAVQC003-011 AAV Appearance Visual Inspection 3
AAVQC003-012 Subvisible Particles
<Light obscuration>		 Light obscuration 3
AAVQC003-013 Osmolarity
<Freezing point >		 Freezing point 3
Contamination AAVQC004-001 Residual Host HEK293 Cell DNA Quantification qPCR 5
AAVQC004-002 Residual HEK293 Host Cell DNA Sizing qPCR 5
AAVQC004-003 Residual Plasmid DNA ddPCR 5
AAVQC004-004 Residual E1A ddPCR 5
AAVQC004-005 Residual Host Cell Protein ELISA 5
AAVQC004-006 Residual BSA ELISA 5
AAVQC004-007 Residual Nuclease ELISA 5
AAVQC004-008 Residual Affinity Ligands ELISA 5
AAVQC004-009 Residual PEI HPLC 5
AAVQC004-010 Residual Tween20 HPLC 5
AAVQC004-011 Residual Triton X100 HPLC 5
AAVQC004-012 Residual Iodixanol HPLC 5
AAVQC004-013 Residual Poloxamer 188 HPLC 5
AAVQC004-015 Residual Triton Analysis
(bundle with endo removal)		 HPLC 5
Safety AAVQC005-001 Endotoxin removal Triton 2-3
AAVQC005-002 Sterility test Innoculation 14-20
AAVQC005-003 Mycoplasma detection Gel 2-3
AAVQC005-004 Endotoxin test LAL 3
AAVQC005-005 Quantitative Endotoxin test Kinetic Chromogenic Assays 3
AAVQC005-006 Bioburden Test Plate count method 5
AAVQC005-007 Mycoplasma detection by qPCR qPCR 2-3
AAVQC005-008 Replication Competent AAV (rcAAV) Analysis Infection on Permissive Cells 21

Performance

  • AAV Genome Titer by ddPCR

    Provides precise quantification of viral genome copies, ensuring accurate assessment of viral load. This is essential for determining effective dosages and maintaining batch-to-batch consistency in gene therapy applications. Learn more about AAV genome titer by ddPCR

    AAV genome titer by ddPCR

    AAV genome titer by ddPCR

  • AAV Genome Integrity by CE

  • AAV Genome Sequencing by Nanopore

  • AAV Empty Capsid Rate Test by AUC

  • Replication Competent AAV (rcAAV) Analysis

  • AAV Capsid Characterization

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