π-Omega Plasmid DNA High-yield Production Platform

PackGene’s proprietary π-Omega Plasmid DNA High-yield Platform increases plasmid yield by more than 3 times through plasmid backbone modifications. Production scale can reach up to 200L, and single-batch production yields can reach up to 100 grams. As a key raw material in AAV production, plasmid DNA cost reduction greatly reduces AAV production cost while simultaneously meeting the growingly plasmids demand in the mRNA based therapeutics.

Key Advantages

Cost Efficient

Greatly reduces cost by two-step chromatography
Increase Yield

High-yield plasmid production driven by proprietary plasmid backbone modifications
Quality

Strain suitable for mRNA plasmid fermentation (maintaining the stability of polyA)

One patent is pending.

Increases Yield about 3-4 times by Molecular Modification on Plasmid

Two-step Purification Process to Improve Plasmid Quality

Items	3-step	2-step
HCD	＜5ug/mg	＜2ug/mg
Supercoil	＞95%	＞95%
Endotoxin	＜10EU/mg	＜10EU/mg
HCP	N/A	N/A
Recovery	＞40%	＞50%
Remark	stability	High requirements for upstream stability

Lower HCD & Higher Recovery Rate

Yield of plasmid maintains in the same range

Subscribe for the latest news, press, and updates from PackGene.