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π-Alpha 293 AAV High-yield Production Platform

  • PackGene's proprietary π-Alpha 293 AAV High-Yield Platform represents a significant advancement in Adeno-Associated Virus (AAV) production and quality. The platform integrates an optimized PCS3.0 suspension cell line and a uniquely engineered RC plasmid within a triple-plasmid transfection system, achieving a 3 to 8-fold increase in AAV production across diverse serotypes. This foundational enhancement, coupled with rigorous Quality by Design (QbD) optimizations throughout both upstream and downstream processes, culminates in up to a 10-fold overall yield improvement. The platform consistently delivers single-batch yields reaching 1E+17 vg, effectively meeting the demands of clinical and commercial-scale AAV production.

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Key Advantages

  • Enhanced Productivity and Scalability

    Proprietary technologies drive a greater than 10-fold increase in AAV yield within HEK293 serum-free cell suspension systems. 

  • Superior Purity

    Refined process development significantly reduces key impurities, including Host Cell DNA (HCD) and endotoxin. 

  • Improved Safety and Bioactivity

    Innovative technological advancements minimize empty capsid and maximize infection titers.

Performance

  • Enhanced Productivity and Scalability

    The PCS3.0 suspension cell line, combined with a uniquely engineered RC plasmid, enhances AAV production efficiency. This optimized system enables greater scalability for large-scale manufacturing.

    PackGene’s proprietary RC plasmid significantly increases AAV production yield

    Fig 1. PackGene’s proprietary RC plasmid significantly increases AAV production yield

     

    Enhanced-Productivity-and-Scalability

  • Superior Purity

  • Improved safety and bioactivity

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