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Development of a one-step RT-ddPCR method to determine the expression and potency of AAV vectors
Author:
Pete Clarner, Shukkwan K. Lau, Twinkle Chowdhury, Edward Guilmette, Patrick Trapa, Shih-Ching Lo, and Shen Shen
Journal: Mol Ther Methods Clin Dev
Doi: https://www.doi.org/10.1016/j.omtm.2021.05.003
May 14 2021 -
Eliminating base-editor-induced genome-wide and transcriptome-wide off-target mutations
Author:
Lijie Wang, Wei Xue, Hongxia Zhang, Runze Gao, Houyuan Qiu, Jia Wei, Lina Zhou, Yun-Ni Lei, Xiaocheng Wu, Xiao Li, Chengfang Liu, Jing Wu, Qiubing Chen, Hanhui Ma, Xingxu Huang, Cheguo Cai, Ying Zhang, Bei Yang, Hao Yin, Li Yang and Jia Chen
Journal: Nature Cell Biology
Doi: https://www.doi.org/10.1038/s41556-021-00671-4
May 01 2021 -
Prevalence of Adeno-Associated Virus 3 Capsid Binding and Neutralizing Antibodies in Healthy and Hemophilia B Individuals from India
Author:
Hubert D.-J. Daniel, Sanjay Kumar, Rajesh Kannangai, Kavitha M. Lakshmi, Mavis Agbandje-Mckenna, Kirsten Coleman, Arun Srivastava, Alok Srivastava, and Asha Mary Abraham
Journal: Human Gene Therapy
Doi: https://www.doi.org/10.1089/hum.2020.258
Apr 23 2021 -
Differential development and electrophysiological activity in cultured cortical neurons from the mouse and cynomolgus monkey
Author:
Xue-Yan Zhang, Jun Li, Cai-Juan Li, Ying-Qi Lin, Chun-Hui Huang, Xiao Zheng, Xi-Chen Song, Zhu-Chi Tu, Xiao-Jiang Li, and Sen Yan
Journal: Neural Regen Res
Doi: https://www.doi.org/10.4103/1673-5374.313056
Apr 23 2021 -
Human ACE2-Functionalized Gold “Virus-Trap” Nanostructures for Accurate Capture of SARS-CoV-2 and Single-Virus SERS Detection
Author:
Yong Yang, Yusi Peng, Chenglong Lin, Li Long, Jingying Hu, Jun He, Hui Zeng, Zhengren Huang, Zhi-Yuan Li, Masaki Tanemura, Jianlin Shi, John R. Lombardi, and Xiaoying Luo
Journal: Nanomicro Lett
Doi: https://www.doi.org/10.1007/s40820-021-00620-8
Apr 13 2021 -
In vivo genome editing in mouse restores dystrophin expression in Duchenne muscular dystrophy patient muscle fibers
Author:
Menglong Chen, Hui Shi, Shixue Gou, Xiaomin Wang, Lei Li, Qin Jin, Han Wu, Huili Zhang, Yaqin Li, Liang Wang, Huan Li, Jinfu Lin, Wenjing Guo, Zhiwu Jiang, Xiaoyu Yang, Anding Xu, Yuling Zhu, Cheng Zhang, Liangxue Lai, and Xiaoping Li
Journal: Genome Medicine
Doi: https://www.doi.org/10.1186/s13073-021-00876-0
Apr 12 2021 -
Use of CRISPR/Cas9-mediated disruption of CNS cell type genes to profile transduction of AAV by neonatal intracerebroventricular delivery in mice
Author:
Tess Torregrosa, Sydney Lehman, Sam Hana, Galina Marsh, Shanqin Xu, Kathryn Koszka, Nicole Mastrangelo, Alexander McCampbell, Christopher E. Henderson, and Shih-Ching Lo
Journal: Gene Therapy
Doi: https://www.doi.org/10.1038/s41434-021-00223-3
Feb 22 2021 -
Hepatocyte-targeting and microenvironmentally responsive glycolipid-like polymer micelles for gene therapy of hepatitis B
Author:
Jing Miao, Xiqin Yang, Xuwei Shang, Zhe Gao, Qian Li, Yun Hong, Jiaying Wu, Tingting Meng, Hong Yuan, and Fuqiang Hu
Journal: Mol Ther Nucleic Acids
Doi: https://www.doi.org/10.1016/j.omtn.2021.02.013
Feb 18 2021 -
Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models
Author:
Yingjun Li, Liu Cao, Ge Li, Feng Cong, Yunfeng Li, Jing Sun, Yinzhu Luo, Guijiang Chen, Guanguan Li, Ping Wang, Fan Xing, Yanxi Ji, Jincun Zhao, Yu Zhang, Deyin Guo, and Xumu Zhang
Journal: J Med Chem
Doi: https://www.doi.org/10.1021/acs.jmedchem.0c01929
Feb 01 2021 -
The immunodominant and neutralization linear epitopes for SARS-CoV-2
Author:
Shuai Lu, Xi-xiu Xie,Lei Zhao, Bin Wang, Jie Zhu, Ting-rui Yang, Guang-wen Yang, Mei Ji, Cui-ping Lv, Jian Xue, Er-hei Dai, Xi-ming Fu, Dong-qun Liu, Lun Zhang, Sheng-jie Hou, Xiao-lin Yu, Yu-ling Wang, Hui-xia Gao, Xue-han Shi, Chang-wen Ke, Bi-xia Ke, Chun-guo Jiang, and Rui-tian Liu
Journal: Cell Reports
Doi: https://www.doi.org/10.1016/j.celrep.2020.108666
Jan 26 2021 -
Combined analysis of the transcriptomes and proteomics of different cerebral areas between young and aging macaca mulatta
Author:
Lan-Lan Shi
Journal: Imedicine
Dec 31 2020 -
Connexin-36-expressing Gap Junctions in VTA GABA Neurons Sustain Opiate Dependence
Author:
Geith Maal-Bared, Mandy Yee, Erika K. Harding, Martha Ghebreselassie, Michael Bergamini, Roxanne Choy, Ethan Kim, Stephanie Di Vito, Maryam Patel, Mohammadreza Amirzadeh, Taryn E. Grieder, James I. Nagy, Robert P. Bonin and Derek van der Kooya
Journal: BioRxiv
Doi: https://www.doi.org/10.1101/2020.12.18.423554
Dec 21 2020