HBV Genotype-AAV

Therefore, mice with a uniform genetic background remain the best choice for researchers to conduct HBV research. The rAAV virus vector carry 1.3×HBV full-length genome, and the mouse model of persistent HBV infection is prepared by one-time tail vein injection. Such method shows advantages include simple preparation, high success rate, uniformity and stability, obvious dose-effect relationship, and wide application range. HBV-AAV has been widely used in HBV drug evaluation and vaccine screening.
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Features of HBV rAAV vector
Highest security
Long-term transduction
Organ Specificity
Our Advantages
- High purity titer ≥1E+13GC/ml shown in terms of AAV8-based qPCR genome copies/ml
- Low endotoxin lower than 10EU/ml, suitable for animal experiments.
- AAV-HBV Mycoplasma test negative.
- Low empty shell: AAV-HBV TEM detects empty shell rate is below 30%.
- Complete quality inspection reports are provided.
AAV Type
Genotype
Vector
Remark
AAV Type: AAV8-HBV-0001
Genotype: HBV-D genotype, AYW genotype
Vector: HBV-D-AYW 1.3
Remark: Epidemic worldwide and in part of China
AAV Type: AAV8-HBV-0002
Genotype: HBV-C genotype, ADR genotype
Vector: HBV-C-ADR 1.3
Remark:Mainly epidemic in Asia and China with strong pathogenicity
AAV Type: AAV8-HBV-0003
Genotype: HBV-C2, replication defective
Vector: HBV-C-YMHA-1.3
Remark: Epidemic in Asia
AAV Type: AAV8-HBV-0001
Genotype: HBV-B genotype, ADW genotype
Vector: HBV-B-Adw 1.3
Remark: Mainly epidemic in Asia and China with less pathogenicity compared with HBV-C type
Operation Requirements
Storage Requirements
- Store the virus at -80°C, take it out when needed, and place it on ice during operation. Fast Service must be used within 24 hours.
- Calculate the usage in advance, and PackGene will sub-pack the virus according to the predetermined requirements before shipping to avoid re-freezing and thawing sub-packaging after receiving the goods, which might affect the titer accuracy. If sub-packaging is required, it is recommended to use PCR tubes with siliconized inner wall, or special virus preservation tubes with low protein binding rate.
- Melt the virus in an ice bath and dilute with PBS or PBS / 0.001% F-68, if you need to dilute the AAV-HBV.
Liver Infection
Design of AAV-HBV Mouse Modeling
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