SAN DIEGO, Calif., September 12, 2024 – Vironexis Biotherapeutics has launched from stealth, announcing FDA clearance of its IND application for VNX-101, a gene therapy targeting CD19+ acute lymphoblastic leukemia. This marks the first-ever clinical trial of an AAV-delivered cancer immunotherapy, expected to begin in Q4 2024.
Vironexis’s TransJoin™ platform aims to improve cancer treatments through safer, single-dose, off-the-shelf gene therapies that target cancer cells continuously. The company has built a pipeline of over ten candidates, including therapies for blood cancers, solid tumor metastasis prevention, and a cancer vaccine.
“Our technology leverages AAV to enhance the safety, efficacy, and durability of T-cell immunotherapies, potentially overcoming limitations of current treatments,” said CEO Samit Varma.
The $26 million seed financing, led by Drive Capital and Future Ventures, will support Vironexis’s plans to advance its lead programs into clinical trials by 2025. Founded on research from Nationwide Children’s Hospital, Vironexis’s approach uses AAV vectors to deliver engineered transgenes that enable continuous T-cell targeting of tumors.
About Vironexis Biotherapeutics
Vironexis Biotherapeutics is pioneering AAV-delivered T-cell immunotherapy to transform cancer treatment. The TransJoin™ platform offers off-the-shelf, single-dose therapies designed to improve current immunotherapy challenges.
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